The updated 2020 NTM Treatment Guidelines* now recommend ARIKAYCE

  • Adding ARIKAYCE to a multidrug regimen is now strongly recommended for people with MAC lung disease who continue to test positive after at least 6 months of a multidrug regimen alone
  • The guidelines were created by leading scientific communities to provide recommendations and standards for NTM treatment

Start treatment after MAC lung disease is diagnosed

Multidrug regimen icon
The guidelines recommend a multidrug regimen of at least 3 antibiotics

The guidelines suggest starting treatment rather than waiting . . . READ MORE

1 → 5 months after treatment initiation

1-2 months icon
Get sputum tested every 1-2 months

The guidelines recommend regular doctor visits and monthly sputum cultures . . . READ MORE

6 months after starting treatment

Scroll to see recommendation

The guidelines recommend that doctors evaluate if the multidrug regimen is working after 6 months of treatment.

NO. I am still

The guidelines recommend adding ARIKAYCE for people who continue to test positive after 6 months of treatment

ARIKAYCE was approved by FDA using the Limited Population pathway for a limited and specific patient population.

YES. I have tested


Additional guidelines recommendation

The guidelines recommend staying on treatment for a minimum of 12 months after testing negative for MAC. This is to help make sure the MAC bacteria is cleared from your lungs.

12 months icon


ATS=American Thoracic Society; ERS=European Respiratory Society; ESCMID=European Society of Clinical Microbiology and Infectious Diseases; IDSA=Infectious Diseases Society of America.

Helpful tools for talking to your doctor

Questions to ask your doctor about ARIKAYCE

Download these important questions to ask your doctor about ARIKAYCE, so you can make the most of your next appointment

Treatment Plan Guide

Use this tool to help you talk to your doctor about establishing a treatment plan, so you can keep track of what to expect plus your treatment goals and progress

Side Effect Management Tips

Bring this list of potential side effect management techniques to your next doctor appointment and note any techniques you and your doctor may want to try


Learn important information about ARIKAYCE, including what to expect from treatment, an overview of the Arikares® Support Program, plus helpful questions to ask your doctor

Find a specialist

If you think you might have MAC lung disease, or if you’ve already been diagnosed, you may wish to see a doctor in your area who specializes in lung disease. Click the links below to help you find a specialist who can help.


Visit NTM Info & Research (NTMir) to find a comprehensive list of physicians with experience treating NTM lung disease


Zocdoc allows you to find a physician by searching for a specific disease or condition

American Medical Association

The American Medical Association's doctor finder allows you to search for a physician by specialty and filter the results by location

Connect with others

Click to explore communities for people with NTM lung disease

NTM Info & Research Support Groups

NTMir has local support groups that hold regular meetings, as well as online forums for NTM patients, loved ones, physicians, and researchers

Bronch and NTM 360 Social

This online community is for people affected by bronchiectasis and NTM lung disease, including patients, family members, caregivers, and doctors. It is an online home to help share thoughts and ideas, ask questions, and start discussions


Inspire™ is home to online communities for those living with or affected by lung disease, where you can find peer-to-peer support

Resources and tools to help with your treatment

ARIKAYCE in Action Video

An informative video on how ARIKAYCE treats MAC lung disease

Device Video

A step-by-step demonstration of how to assemble, use, and clean the Lamira® Nebulizer System to take ARIKAYCE

ARIKAYCE Quick Start Guide

An overview of how to assemble and clean your Lamira Nebulizer System, as well as directions and diagrams demonstrating how to take your treatment

Lamira Nebulizer System Instructions for Use

Comprehensive instructions on how to use and care for your Lamira Nebulizer System, with directions and techniques to deal with situations that may come up during use

ARIKAYCE Prescribing Information (English)

The Prescribing Information for ARIKAYCE is available in several languages

Watch videos of patients and physicians discussing their real stories
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IMPORTANT SAFETY INFORMATION AND INDICATION ARIKAYCE is associated with: risk of increased respiratory adverse reactions including allergic inflammation of lungs, coughing up blood, severe breathing problems and worsening of COPD.

ARIKAYCE can cause serious side effects, including:

  • allergic inflammation of the lungs. These respiratory problems may be symptoms of allergic inflammation of the lungs and often come with fever, wheezing, coughing, shortness of breath, and fast breathing
  • coughing up of blood (hemoptysis). Coughing up blood is a serious and common side effect of ARIKAYCE
  • severe breathing problems. Severe breathing problems can be symptoms of bronchospasm. Bronchospasm is a serious and common side effect of ARIKAYCE. Bronchospasm symptoms include shortness of breath, difficult or labored breathing, wheezing, and coughing or chest tightness
  • worsening of chronic obstructive pulmonary disease (COPD). This is a serious and common side effect of ARIKAYCE
  • serious allergic reactions. Serious allergic reactions that may lead to death have happened to people who take ARIKAYCE. Stop taking ARIKAYCE right away and get emergency medical help if you have any of the following symptoms of a serious allergic reaction: hives, itching, redness or blushing of the skin (flushing), swollen lips, tongue or throat, trouble breathing or wheezing, shortness of breath, noisy high-pitched breathing (stridor), cough, nausea, vomiting, diarrhea, feel cramps in your stomach area, fast heart rate, feeling light headed, feeling faint, loss of control of the bowels or bladder (incontinence), and dizziness

While using ARIKAYCE, these side effects may become serious enough that treatment in a hospital is needed. Call your healthcare provider or get medical help right away if you have any of these serious side effects while taking ARIKAYCE. Your healthcare provider may ask you to stop using ARIKAYCE for a short period of time or completely stop using ARIKAYCE.

Do not use ARIKAYCE if you are allergic to any aminoglycoside, or any of the ingredients in ARIKAYCE.

Before using ARIKAYCE, tell your healthcare provider about all medical conditions, including if you:

  • have asthma, COPD, shortness of breath, or wheezing (bronchospasm)
  • have been told you have poor lung function
  • have hearing problems, such as ringing in your ears or hearing loss
  • have dizziness or a sense of the room spinning
  • have kidney problems
  • have neuromuscular disease, such as myasthenia gravis
  • are pregnant or plan to become pregnant. It is not known if ARIKAYCE can harm your unborn baby. ARIKAYCE is in a class of medicines that may be connected with complete deafness in babies at birth. The deafness affects both ears and cannot be changed
  • are breastfeeding or plan to breastfeed. It is not known if the medicine in ARIKAYCE passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby during treatment with ARIKAYCE

Tell your healthcare provider about all the medicines you take, including prescription medicines and over-the-counter medicines, vitamins, and herbal supplements.

ARIKAYCE may cause serious side effects, including:

  • hearing loss or ringing in the ears (ototoxicity). Ototoxicity is a serious and common side effect of ARIKAYCE. Tell your healthcare provider right away if you have hearing loss or you hear noises in your ears, such as ringing or hissing. Tell your healthcare provider if you start having problems with balance or dizziness (vertigo)
  • worsening kidney problems (nephrotoxicity). ARIKAYCE is in a class of medicines which may cause worsening kidney problems. Your healthcare provider may do a blood test to check how well your kidneys are working during your treatment with ARIKAYCE
  • worsening muscle weakness (neuromuscular blockade). ARIKAYCE is in a class of medicines which can cause muscle weakness to get worse in people who already have problems with muscle weakness (myasthenia gravis)

The most common side effects of ARIKAYCE include: changes in voice and hoarseness (dysphonia), cough during or after a dose of ARIKAYCE, especially in the first month after starting treatment, muscle pain, sore throat, tiredness (fatigue), diarrhea, nausea, headache, fever, decreased weight, vomiting, rash, increased sputum, or chest discomfort.

These are not all of the possible side effects of ARIKAYCE. Call your doctor or pharmacist for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or


ARIKAYCE is a prescription medicine used to treat adults with refractory (difficult to treat) Mycobacterium avium complex (MAC) lung disease as part of a combination antibacterial drug treatment plan (regimen).

It is not known if ARIKAYCE is safe and effective in children younger than 18 years of age.

This product was approved by FDA using the Limited Population pathway. This means FDA has approved this drug for a limited and specific patient population, and studies on the drug may have only answered focused questions about its safety and effectiveness.

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