What is ARIKAYCE?
ARIKAYCE is an antibacterial drug that is delivered to the lungs
Prescription ARIKAYCE is an inhaled, liposomal form of the antibiotic amikacin. In ARIKAYCE, the amikacin is contained inside tiny particles called liposomes. These liposomes are designed to help the medicine reach the lungs.
How does ARIKAYCE work?
When you inhale ARIKAYCE, the liposomes containing the medicine travel into your lungs. There, they enter the body's cells, called macrophages, where the MAC bacteria can live.
Watch the video below to see ARIKAYCE in action.
A look at the ARIKAYCE study
ARIKAYCE + combination antibacterial drug treatment plan was studied in 224 adult patients who had been diagnosed with MAC lung disease.
In order to participate in this study, all of the patients had previously been treated with a combination antibacterial drug treatment alone. And they did not respond to treatment.
3X as many people tested negative for MAC lung disease 6 months after being on ARIKAYCE + combination antibacterial drug treatment plan vs those on a combination antibacterial drug treatment alone
Among all patients in the study, 27.7% (62/224) of patients on ARIKAYCE + combination antibacterial drug treatment plan still tested negative for MAC lung disease after 6 months. This was compared to 6.3% (7/112) of patients on combination antibacterial drug treatment alone after 6 months.
Among the patients who tested negative for MAC lung disease during the study, 95.4% (62/65) of people taking ARIKAYCE + combination antibacterial drug treatment plan still tested negative for MAC lung disease after 6 months. This was compared to 70% (7/10) of the people taking the combination antibacterial drug treatment alone, who still tested negative for MAC lung disease after 6 months.
What are the side effects of ARIKAYCE?
- allergic inflammation of the lungs. These respiratory problems may be symptoms of allergic inflammation of the lungs and often come with fever, wheezing, coughing, shortness of breath, and fast breathing
- coughing up of blood (hemoptysis). Coughing up blood is a serious and common side effect of ARIKAYCE
- severe breathing problems. Severe breathing problems can be symptoms of bronchospasm. Bronchospasm is a serious and common side effect of ARIKAYCE. Bronchospasm symptoms include shortness of breath, difficult or labored breathing, wheezing, and coughing or chest tightness
- worsening of chronic obstructive pulmonary disease (COPD). This is a serious and common side effect of ARIKAYCE
While using ARIKAYCE, these side effects may become serious enough that treatment in a hospital is needed. Call your healthcare provider or get medical help right away if you have any of these serious side effects while taking ARIKAYCE. Your healthcare provider may ask you to stop using ARIKAYCE for a short period of time or completely stop using ARIKAYCE.
- hearing loss or ringing in the ears (ototoxicity). Ototoxicity is a serious and common side effect of ARIKAYCE. Tell your healthcare provider right away if you have hearing loss or you hear noises in your ears such as ringing or hissing. Tell your healthcare provider if you start having problems with balance or dizziness (vertigo)
- worsening kidney problems (nephrotoxicity). ARIKAYCE is in a class of medicines which may cause worsening kidney problems. Your healthcare provider may do a blood test to check how well your kidneys are working during your treatment with ARIKAYCE
- worsening muscle weakness (neuromuscular blockade). ARIKAYCE is in a class of medicines which can cause muscle weakness to get worse in people who already have problems with muscle weakness (myasthenia gravis)
Do not use ARIKAYCE if you are allergic to any aminoglycoside, or any of the ingredients in ARIKAYCE.
- changes in your voice and hoarseness (dysphonia)
- sore throat
- muscle pain
- tiredness (fatigue)
- decreased weight
- increased sputum
- chest discomfort
- cough during or after a dose of ARIKAYCE, especially in the first month after starting treatment
If you experience any side effects while on treatment
Be sure to tell your doctor
Tell your doctor about all the medicines you take. This includes prescription medicines and over-the-counter medicines, vitamins, and herbal supplements. Keep a list of the medicines you take and show your doctor and pharmacist when you get a new medicine.
Find sample questions to help you start a conversation about ARIKAYCE with your doctor by downloading this
To learn how to take ARIKAYCE, watch the